ISOLATED CHIMERIC PROTEINS OF MODIFIED LUMAZINE SYNTHASE

摘要

isolated chimeric proteins including up to ten copies of peptides,polypeptides or protein domains inserted in the amino termini of the Brucellaspp. Lumazine synthase enzyme. Isolated nucleotide sequences codifying thechimeric proteins. Vectors, plasmids and transformed cells used for expressingthe proteins. Monoclonal and polyclonal antibodies induced by the chimericproteins. Hybridomas producing the monoclonal antibodies. Vaccines andpharmaceutical compounds including the chimeric proteins, nucleotide sequencesand antibodies. A method to induce an immune response in higher organismsincluding the administration of effective amounts of the vaccines andpharmaceutical compounds. Biosensors including the chimeric proteins. Proteinconjugates formed by the chimeric proteins and a ligand bound by means ofcovalent and noncovalent bonds. Uses of the chimeric proteins, nucleotidesequences, vectors, plasmids, transformed cells, antibodies, hybridomas,conjugates, biosensors, vaccines and pharmaceutical compounds. The quaternarystructure of the chimeric proteins.