prion-free nanopaticle compositions and methods for their manufacture

摘要

Provided herein is a composition comprising nanoparticles comprising a substantially water insoluble pharmacologically active agent coated with albumin, and a ligand capable of binding to a prion protein. Also provided is a mixture comprising an albumin solution, an organic phase comprising a substantially water insoluble pharmacologically active agent dispersed in an organic solvent, and a ligand capable of binding a prion protein.