T-CELL, WHICH EXPRESSES T-CELL RECEPTOR (TCR) GAMMA-DELTA AND CHEMERIC ANTIGEN RECEPTOR (CAR)

摘要

The present invention relates to a T-cell that expresses a gamma-delta T-cell receptor (TCR) and a chimeric antigen receptor (CAR), where CAR contains an antigen-binding domain; a transmembrane domain and a costimulatory intracellular signaling domain, where the intracellular signal domain generates a costimulatory signal for a T-cell after antigen binding to an antigen-binding domain.