COMPOSITIONS AND METHODS OF RESENSITIZING CELLS TO BROMODOMAIN AND EXTRATERMINAL DOMAIN PROTEIN INHIBITORS (BETi)

摘要

The present invention provides compositions and methods to increase anti-tumor sensitivity of a cell or tumor to bromodomain and extraterminal domain protein inhibitors (BETi). In one aspect, a composition comprises a BETi and a TGFβ pathway inhibitor, TRIM33 or a fragment thereof, or a nucleic acid encoding TRIM33. In another aspect, a method is described for increasing anti-tumor sensitivity to BETi. Methods for a tumor with BETi are also described.