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Secreted splicing variant of mammal Klotho as a medicament for cognition and behaviour impairments
Secreted splicing variant of mammal Klotho as a medicament for cognition and behaviour impairments
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机译:哺乳动物Klotho的秘密剪接变体作为认知和行为障碍的药物
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摘要
The invention discloses using secreted splicing variant of mammal Klotho (s- KL) as an agent for the prevention and/or treatment of cognitive and/or behaviour impairments. It also refers to gene constructs and expression vectors useful in gene therapy for the delivery of said s-KL variant to the central nervous system of a mammal, in particular a rodent or a human. Pharmaceutical compositions comprising either the protein s-KL or any gene construct for expressing the protein in the CNS are also disclosed.
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