ANTISENSE OLIGONUCLEOTIDE WITH REDUCED SIDE EFFECTS

摘要

The present invention addresses the problem of providing an antisense oligonucleotide (ASO) with reduced side effects. To solve this problem, provided is an ASO having a structure, wherein phosphodiester bonds occurring naturally between oligonucleotides and phosphorothioate bonds obtained by substituting one of oxygen atoms in a phosphate group by a sulfur atom are alternately positioned, as an antisense activity site.