Leprosy drug intermediates p-isothiocyanolobutyl ether synthesis method

摘要

#$%^&*AU2018101113A420180906.pdf#####6 Leprosy drug intermediates pisothiocyanolobutyl ether synthesis method Abstract 5 The present invention discloses leprosy drug intermediates p-isothiocyanolobutyl ether synthesis method, comprises the following steps: 3-bromo-4-amino-5-methylphenylbutyl ether is added to the reaction vessel at a temperature, sodium sulfate solution and thionyl dichloride solution are added, the stirring rate is controlled, reacts; continues to add the bromine aqueous solution, raises 10 the temperature, ammonium chloroplatinate powder is added in batches, continues to react, and then reduces the temperature, standing, after solution layers, separated the oil layer, washed with potassium bromide solution for several times, washed with 3-pentanol solution for several times, recrystallizes in the bromopropane solution, dehydrated with dehydration, gets the finished product p-isothiocyanolobutyl ether.