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HIGH-THROUGHPUT AND SINGLE NUCLEOTIDE RESOLUTION TECHNIQUES FOR THE DETERMINATION OF RNA POST-TRANSCRIPTIONAL MODIFICATIONS
HIGH-THROUGHPUT AND SINGLE NUCLEOTIDE RESOLUTION TECHNIQUES FOR THE DETERMINATION OF RNA POST-TRANSCRIPTIONAL MODIFICATIONS
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机译:高通量和单核苷酸分离技术用于RNA转录后修饰的测定
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摘要
Disclosed herein are methods and associated compositions and kits for identifying nucleoside modifications. Particularly exemplified herein are methods that involve inducing base misincorporation at locations in an RNA that harbor a nucleoside modification. The resulting cDNA can then be subjected to next generation sequencing to identify mutations with respect to a reference sequence. Moreover, the type of nucleoside modification can be determined based on the substitution pattern of a given nucleoside modification.
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