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METHOD FOR IDENTIFYING MITOCHONDRIAL DNA IN EXTRACELLULAR VESICLES AND TREATMENT OF MTDNA-RELATED DISORDERS AND CANCER
METHOD FOR IDENTIFYING MITOCHONDRIAL DNA IN EXTRACELLULAR VESICLES AND TREATMENT OF MTDNA-RELATED DISORDERS AND CANCER
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机译:鉴定细胞外血管中线粒体DNA的方法及MTDNA相关疾病和癌症的治疗
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摘要
Isolation of large quantities of mtDNA from cancer patient circulating microvesicles and exosomes as well as cell lines including fibroblasts and bone marrow stromal cells provides a useful biological tool -microvesicles derived mtDNA- to quantify mtDNA, diagnose and study mitochondria disorders and transfer molecules of mtDNA in recipient cells (mtDNA genetic therapy). The treatment of hormonal therapy derived dormant cancer cells with CAF-derived mtDNAM EVs promotes an escape from metabolic quiescence and hormonal therapy resistant disease both in vitro and in vivo.
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