GENERATION OF MONOCLONAL ANTIBODIES TARGETING RESPIRATORY SYNCYTIAL VIRUS (RSV) USING REGULATORY B CELLS FROM NEWBORNS (NBREGS)

摘要

The invention pertains to methods for preparing libraraies of antibodies or fragments thereof, and methods for preparing a monoclonal antibody or fragments thereof that bind, preferably specifically, to an antigen of interest, based on the use of nBreg cells. The invention further pertains to the antibody library susceptible to be produced by the methods of the invention. The invention further pertains to the monoclonal antibodies and fragments thereof susceptible to be produced by the methods of the invention, as well as the monoclonal antibodies derived from the antibody library, the pharmaceutical compositions comprisising thereof, and their use as a medicine. The invention more particularly pertains to monoclonal antibodies derived from nBregs can be used for prophylactic and therapeutic purposes for RSV infections.