The present invention relates to a composition for preventing, ameliorating or treating osteoporosis comprising kirenol or an extract of Hui Chum ( Siegesbeckia spp.) Containing the same as an active ingredient. The kirenol according to the present invention, or the extract of the present invention containing the same or a fraction thereof, has an excellent effect for preventing, improving or treating osteoporosis as it promotes osteoblast differentiation and inhibits osteoclastogenesis. In addition, since the present invention is a natural product, it can be safely used without side effects and can be used as a medicine or food.
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