heterodimeric Fc IL-21 heterodimeric Fc-fused IL-21 Heterodimeric Fc-fused IL-21 and Pharmaceutical Composition Comprising the Same

摘要

The present invention relates to a heterodimer fusion protein (heterodimeric Fc-fused protein) and a pharmaceutical composition comprising the heterodimeric Fc-fused protein. The heterodimeric Fc-fused protein includes a first Fc region and a second Fc region of an immunoglobulin heavy chain constant region pair, and has IL-21 bound to at least one of N-terminal or C-terminal of the first Fc region and/or the second Fc region, wherein the first Fc region and the second Fc region are mutated in the CH3 domain to facilitate formation of heterodimers. When the heterodimeric Fc-fused protein of the immunoglobulin heavy chain constant region according to the present invention is used, the in vivo half-life of IL-21 included in the heterodimeric Fc-fused protein can be remarkably increased.