heterodimeric Fc IL-21 heterodimeric Fc-fused IL-21 Heterodimeric Fc-fused IL-21 and Pharmaceutical Composition Comprising the Same

摘要

The present invention encompasses a fusion protein comprising a first Fc region and a second Fc region of a heavy chain constant region pair of an antibody (immunoglobulin), wherein at least one of the N-terminal or C-terminal ends of the first Fc region and / Wherein the first Fc region and the second Fc region are mutated in such a manner that the formation of a heterodimer is promoted in the heterodimeric Fc-fused protein wherein IL-21 is bound to the IL-21, And a heterodimeric Fc-fused protein and a heterologous duplex-fusion protein. When the antibody heavy chain constant region heterologous duplex-fusion protein according to the present invention is used, the half-life of the IL-21 contained in the heterologous duplex-fusion protein can be remarkably increased.