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Solid dispersions comprising Telmisartan and the preparation method thereof

机译:包含替米沙坦的固体分散体及其制备方法

摘要

The solid dispersions comprising telmisartan and a manufacturing method thereof, according to the present invention, unlike conventional methods requiring a low yield, can manufacture telmisartan of a high yield through simple and short steps by using a relatively inexpensive raw material, can secure excellent quality through reduction of generation of decomposition products, and can manufacture the solid dispersions on a mass production basis to be commercially available. Therefore, the solid dispersions of novel crystalline polymorph of the telmisartan of the present invention has improved storage stability and solubility, and can be synthesized at a high yield, thereby being expected to be very useful in the manufacture of pharmaceuticals.
机译:根据本发明,与要求低产率的常规方法不同,根据本发明的包含替米沙坦的固体分散体及其制备方法,可以通过使用相对便宜的原料通过简单且短的步骤来制备高产率的替米沙坦,并且可以通过减少分解产物的产生,并且可以批量生产固体分散体以使其可商购。因此,本发明替米沙坦的新型结晶多晶型物的固体分散体具有改善的储存稳定性和溶解性,并且可以高收率合成,从而有望在药物制造中非常有用。

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