Phc2 Compositon for regulating migration of hematopoietic stem cell comprising expression inhibitors of Phc2 gene

摘要

The present invention relates to a composition comprising an agent for inhibiting the expression of a polyhomeotic-like protein 2 (Phc2) gene and a composition for treating immunocytopenia comprising the Phc2 gene. The expression inhibitor of VCAM-1 gene or the inhibitor of VCAM-1 protein activity of Phc2 gene according to the present invention promotes migration from hematopoietic stem cell bone marrow to peripheral blood and peripheral tissues and inhibits cell adhesion between stromal cells and hematopoietic stem cells Thereby inhibiting immune cell hypoxia. Furthermore, since the hematopoietic stem cells can be easily obtained, the hematopoietic stem cells can be used for the treatment of hematopoietic diseases requiring hematopoietic stem cell transplantation.