O SEA ME-SA Recombinant foot-and-mouth disease virus expressing protective antigen of type O SEA and ME-SA topotype

摘要

The present invention relates to a recombinant foot-and-mouth disease virus expressing protective antigens of foot-and-mouth disease type O Manisa and Southeast Asia SEA topotypes, and a producing method thereof. The present invention can maximize a protective effect in a wider range with regard to a foot-and-mouth disease type O serotype. A VP1 site of a P1 gene of a foot-and-mouth type O-type Manisa genome is substituted with a VP1 gene of foot-and-mouth disease O-SEA and a 3B12 site of the foot-and-mouth disease O Manisa genome is substituted with a 3B33 site.