Asia1 Shamir Recombinant foot-and-mouth disease virus expressing stable and differential protective antigen of Asian isolates and standard strains

摘要

The present invention relates to a recombinant foot-and-mouth disease virus capable of expressing protective antigens of Asian standard strain Asia1 Shamir and foot-and-mouth disease O-type Asia strain (Asia1 MOG/2005). The present invention further relates to a production method thereof. According to the present invention, it is possible to produce a vaccine in a safe and convenient way since stability and distinction from wild types are secured through manipulation of environmental resistance factors and non-structural proteins while maximizing protective effects in wider range for foot-and-mouth disease O-type serotypes.