RECOMBINANT PLASMID DNA pPicZαA / BChE-14 CONTAINING A MODIFIED HUMAN BUTYRILCHOLINESTERASE GENE INTENDED FOR EXPRESSION OF THE BUTYRILCHOLENEROSIS GENESIS GENESIS

摘要

FIELD: biotechnology.SUBSTANCE: invention relates to biotechnology, particularly to production of human recombinant butyrylcholinesterase (BuChE). Disclosed is a recombinant plasmid DNA pPicZαA/BChE-14 providing a product of modified human butyrylcholinesterase rhBChE-14 and consisting of a nucleotide sequence with SEQ ID NO.:1.EFFECT: invention can be used in medicine in therapy of organophosphorus toxins, for therapy of narcotic substance poisonings of cocaine type, for therapy of consequences of anesthesia in people with endogenous BuChE deficiency.1 cl, 3 dwg, 4 ex