WATER-SOLUBLE PROPOFOL DERIVATIVES AND USES THEREOF

摘要

The present invention discloses a class of water-soluble propofol derivatives, preparation method thereof, anesthetization method using the same, use thereof as prodrugs and use thereof in the preparation of intravenous anesthetics. The water-soluble propofol derivatives have the general formula (I): wherein X is H or F, Y is F or alkyl substituted by one or more F, n is 1, 2, 3, 4, 5 or 6, W is W 1 or W 2 ; W 1 is NR 1 R 2 ·A or R 1 and R 2 are each independently H, alkyl optionally substituted with phenyl, or cycloalkyl, m is 0, 1, 2 or 3, A is a pharmaceutically acceptable acid, W 2 is COOM 1/t or OPO 3 (M) 2/t or PO 3 (M) 2/t ; M is a metal ion, an ammonium ion or a basic amino acid cation which can form a salt with an acid radical; t is the charge number of M.