首页> 外国专利> INOSITOL NICOTINATE CRYSTALLINE FORM A AND PREPARATION METHOD THEREFOR

INOSITOL NICOTINATE CRYSTALLINE FORM A AND PREPARATION METHOD THEREFOR

机译:肌苷烟酰胺晶体形式A及其制备方法

摘要

Provided are an inositol nicotinate crystalline form A and a preparation method therefor. The X-ray powder diffraction analysis, obtained by using Cu-K± ray measurement, of the inositol nicotinate crystalline form A has obvious characteristic diffraction peaks at least at 2¸ values, expressed in degrees, of 7.05, 7.41, 9.74, 17.80, 19.86, 23.57, 25.48 and 26.20 with an error range of +/-0.2°. The preparation method is one of or a mixed crystallization method of two or more of an evaporation crystallization method, a cooling crystallization method or an anti-solvent crystallization method. The process thereof is simple and easy to operate, and has more selectivity; the inositol nicotinate crystalline form A can be prepared by various methods, and the prepared product has a good crystallization degree and high chemical stability; and the inositol nicotinate crystalline form A prepared by the present method does not have the problem that a residual solvent is out-of-limit.
机译:提供了一种肌醇烟酸酯晶形A及其制备方法。通过Cu-K±射线测量获得的烟酸烟酸酯晶形A的X射线粉末衍射分析至少在2°值处具有明显的特征衍射峰,以度表示,分别为7.05、7.41、9.74、17.80, 19.86、23.57、25.48和26.20,误差范围为+/- 0.2°。制备方法是蒸发结晶法,冷却结晶法或反溶剂结晶法中的一种或两种以上的混合结晶法。该工艺简单易操作,选择性更高。可以通过各种方法制备烟酸烟酸肌醇晶型A,制备的产品结晶度好,化学稳定性高。本发明方法制得的肌醇烟酸酯晶型A不存在残留溶剂超标的问题。

著录项

  • 公开/公告号EP3354642A4

    专利类型

  • 公开/公告日2019-05-08

    原文格式PDF

  • 申请/专利权人 WEIFANG SHENGYU PHARMA CO. LTD.;

    申请/专利号EP20160848122

  • 发明设计人 ZHU LIWEI;MEI XUEFENG;WANG JIANRONG;

    申请日2016-09-21

  • 分类号C07D213/803;C07D213/80;A61P9/08;A61K31/435;

  • 国家 EP

  • 入库时间 2022-08-21 12:28:55

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