首页>
外国专利>
DESIGN OF THERAPEUTIC IMMUNOGLOBULIN G4 FOR IMPROVED BIOANALYTICAL AND BIOPROCESSING PROPERTIES
DESIGN OF THERAPEUTIC IMMUNOGLOBULIN G4 FOR IMPROVED BIOANALYTICAL AND BIOPROCESSING PROPERTIES
展开▼
机译:改善免疫分析和生物加工性能的免疫球蛋白G4的设计
展开▼
页面导航
摘要
著录项
相似文献
摘要
In certain embodiments, the disclosure provides an IgG4 antibody comprising a heavy chain and a light chain, wherein the heavy chain comprises: (a) a modified IgG4 CH1 region having a substitution of the lysine residue at position 196; or (b) a modified IgG4 hinge region having a substitution of the serine residue at position 217, the glycine residue at position 220, the proline residue at position 224 or the proline residue at position 225. Preferably, the IgG4 antibody further comprises a substitution of the serine residue at position 228 in the heavy chain hinge region.
展开▼