APPLICATION OF SUBSTITUTED CINNAMAMIDE DERIVATIVES IN PREPARATION OF ANTI-ANXIETY MEDICATIONS

摘要

Disclosed is an application of substituted cinnamamide derivatives in the preparation of anti-anxiety medications, the substituted cinnammide derivatives are compounds having the structure of formula (I) or pharmaceutically acceptable salts thereof, wherein, R₁ is -H, -OH, -F, -Cl, -Br, -I, -OCH₃, -OCF₃, -OCHF₂, -OCH₂F, -CF₃, -CHF₂, -CH₂F, -CH₃, -CH₃CH₂, -CF₃CH₂, -CN, -NO₂, -NH₂ or -COOR₅; R₂ is H, C₁-C₁₀ linear alkyl, C₃-C₁₀ branched alkyl, C₃-C₁₀ cyclic alkyl, C₁-C₁₀ hydroxyalkyl or a N-substituted piperazine-derived group; or R₂ is a group forming with adjacent Y a tetrahydropyrrolyl group, a piperidyl group or a cyclohexanimido group.