APPLICATION OF SUBSTITUTED CINNAMAMIDE DERIVATIVES IN PREPARATION OF ANTI-ANXIETY MEDICATION

摘要

Disclosed is an application of substituted cinnamamide derivatives in the preparation of anti-anxiety medications, the substituted cinnammide derivatives are compounds having the structure of formula (I) or pharmaceutically acceptable salts thereof, wherein, R₁ is —H, —OH, —F, —Cl, —Br, —I, —OCH₃, —OCF₃, —OCHF₂, —OCH₂F, —CF₃, —CHF₂, —CH₂F, —CH₃, —CH₃CH₂, —CF₃CH₂, —CN, —NO₂, —NH₂ or —COOR₅; R2 is H, C₁-C₁₀ linear alkyl, C₃-C₁₀ branched alkyl, C₃-C₁₀ cyclic alkyl, C₁-C₁₀ hydroxyalkyl or a N-substituted piperazine-derived group; or R₂ is a group forming with adjacent Y a tetrahydropyrrolyl group, a piperidyl group or a cyclohexanimido group.;