Direct Preparation of 2-Benzothiazolylzinc Bromide and its Applications: A Facile Synthetic Route to the Preparation of 2-Substituted Benzothiazole Derivatives

摘要

The benzothiazole moiety has been found in a variety of natural products and pharmaceuticals and demonstrates efficient biological activities. Specifically, 2-substituted benzothiazole derivatives have attracted considerable attention in a wide spectrum of chemical applications due to their unique structural properties. Therefore, the diversity of synthetic protocols has been an extensively discussed topic among scientists involved in organic synthesis for the past decades. In general, to build up the 2-substituted benzothiazole complexes, the strategic tools can be categorized as shown in Scheme 1: cross-coupling of benzothiazolylmetallic complexes (method A), coupling reaction of benzothiazole via direct oxidative C-H activation (method B), cross-coupling of organometallic with halobenzothiazole (method C),4 and ring-construction of N and S-containing compounds with the appropriate substrates (method D).