Interleukin-2 tethered to its receptor IL-2Rβ, a platform for enhancing the activity of natural killer cells and regulatory T cells

摘要

A fusion protein comprising IL2 and IL2Rβ (eg CIRB), IL2, IL2Rβ and IL21R (eg CIRB21) and / or a fusion protein comprising IL2, IL2Rβ and CD28 (eg CIRB28); a natural killer (NK) expressing a fusion protein Cells and their use for treating subjects having eg cancer; Regulatory T cells (T-reg) expressing fusion proteins comprising IL2, IL2Rβ and CD28 and treating subjects having eg autoimmune diseases or GVHD How to use them to