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TETHERED INTERLEUKIN-2 TO ITS RECEPTOR IL-2RBETA, A PLATFORM TO ENHANCE NATURAL KILLER AND REGULATORY T CELL ACTIVITY
TETHERED INTERLEUKIN-2 TO ITS RECEPTOR IL-2RBETA, A PLATFORM TO ENHANCE NATURAL KILLER AND REGULATORY T CELL ACTIVITY
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机译:四联体白介素2与其受体IL-2RBETA结合,该平台可增强自然杀手和调节性T细胞活性
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摘要
Fusion proteins comprising IL2 and IL2Rβ (e.g., CIRB), IL2, IL2Rβ and IL21R (e.g., CIRB21), and/or comprising IL2, IL2Rβ, and CD28 (e.g., CIRB28); natural killer (NK) cells that express the fusion proteins and methods of use thereof, e.g., to treat subjects with cancer; and regulatory T cells (T-regs) that express a fusion protein comprising IL2, IL2Rβ, and CD28 and methods of use thereof, e.g., to treat subjects with autoimmune disease or GVHD.
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