Method for producing enzyme-linked small molecule

摘要

PROBLEM TO BE SOLVED: To provide a production method that can effectively stabilize enzyme-bound small molecules.SOLUTION: A production method of enzyme-bound small molecules comprises lyophilizing enzyme (e.g., alkaline phosphatase) -bound small molecules (e.g., thyroid hormone (means triiodothyronine (T3), thyroxine (T4), and the like, as well as may be any of a free type thereof (FT3, FT4) or a binding type to a binding protein), steroid (estradiol, progesterone, cortisol, testosterone, dehydroepiandrosterone sulfate (DHEA-S)), or vitamins (25-hydroxyvitamin D and vitamin Bor folic acid or the like), subsequently dissolving it into a solvent once to make a solution, and subsequently lyophilizing again.SELECTED DRAWING: None