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Methods and apparatus for monitoring interactions between particles and molecules using nanophotonic trapping
Methods and apparatus for monitoring interactions between particles and molecules using nanophotonic trapping
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机译:使用纳米光子俘获监测粒子和分子之间相互作用的方法和装置
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摘要
A method for characterizing an interaction between a first particle and a second particle is provided. The method includes the steps of: (i) providing an optical trap system including a photonics-based trap, a light source, and a camera; (ii) optically trapping, using the photonics-based trap, the first particle; (iii) obtaining a first measurement of a trap stiffness of the photonics-based trap; (iv) introducing the second particle to the optically trapped particle; (v) incubating the first and second particles under conditions suitable for an interaction between the first and second particles; (vi) obtaining a second measurement of the trap stiffness of the photonics-based trap after the incubation; and (vii) determining, using the first measurement of trap stiffness and the second measurement of trap stiffness, a property of the interaction between the first particle and the second particle.
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