DEUTERATED COMPOUNDS FOR TREATING FABRY, GAUCHER, PARKINSON'S AND RELATED DISEASES AND CONDITIONS, AND COMPOSITIONS AND METHODS THEREOF

摘要

Novel deuterium-containing chemical compounds are provided. They are glucosylceramide (GSC) synthase inhibitors and are useful for treating various types of lysosomal storage diseases including Fabry's disease, Gaucher's disease and Parkinson's disease, or related diseases and conditions. Also described are pharmaceutical compositions, and methods of preparation and use thereof.