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Treatment of uncoupling protein 2 (UCP2) related diseases by inhibition of natural antisense transcript to UCP2

机译：通过抑制UCP2的天然反义转录本来治疗解偶联蛋白2（UCP2）相关疾病

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摘要

The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Uncoupling Protein 2 (UCP2), in particular, by targeting natural antisense polynucleotides of Uncoupling Protein 2 (UCP2). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of UCP2.

机译：本发明涉及反义寡核苷酸，其特别是通过靶向解偶联蛋白2（UCP2）的天然反义多核苷酸来调节解偶联蛋白2（UCP2）的表达和/或功能。本发明还涉及这些反义寡核苷酸的鉴定及其在治疗与UCP2表达有关的疾病和病症中的用途。

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公开/公告号US10221413B2

专利类型
公开/公告日2019-03-05

原文格式PDF
申请/专利权人 CURNA INC.;
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申请/专利号US201514723798
发明设计人 JOSEPH COLLARD;OLGA KHORKOVA SHERMAN;
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申请日2015-05-28
分类号C12N15/11;C12N15/113;A61K31/7088;
国家 US
入库时间 2022-08-21 12:09:59

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