NANO-NEUROTOXICITY BIO-MARKER COMPOSITION BASED ON INTRACELLULAR AGGREGATES WHICH ARE BIO-MARKERS OF DEGENERATIVE BRAIN DISEASES

摘要

A method of assessing neurotoxicity of nanoparticles, includes: preparing a tissue or cell sample of mammal exposed to the nanoparticles; analyzing at least one polyamine metabolite selected from the group consisting of putrescine, N1-acetylspermidine, N8-acetylspermidine, N1-acetylspermine and spermine in the sample; and comparing expression degree of the polyamine metabolite with that of a control.