For example, compounds used to address potential defects in the processing of transnational Radical Party active cells. 1. Characteristic 1: A compound expressed in formula (1).Or a drug-acceptable, congenital or stale salt, in which A is a bicyclic heteromorphic organism consisting of 8 to 10 members, consisting of 1, 2 or 3 heteromorphic atoms selected from groups O, N and S, in which bicyclic heteromorphic organisms can be optionally replaced. N 1, 2 or 3 select replacement personnel between RA1;X1 was selected from group N and group C (RX1).X2 was selected from group N and group C (X2);X3 was selected from group N and group C (RX3);Comments more than a month agoX2 or X3 can be N; R1 is selected from a group consisting of - NR7491; R74955;C.C832183318326; asphalt, C832183318326; propoxy, C8383318326; phenylcyclopropylene, a single-ring heteromorphic, consisting of 5-6 members, each with one, two, three or four heteromorphic atoms, independently selected from O, N and S groups, plus a single-ring bicycle bridge heteromorphic; The periodic spiral of 4-10 members, each with one or two different atoms, is independently selected from groups O, N and S, in which the single-ring profiles of 5-6 members may be replaced by one or more substitutes. E. In R7497;]In this regard, alternatives between one, two, three or four independently selected R758484 can be chosen to replace single-ring, double-ring bridges and 4-10 spiral heterocyclic bicycles.If this isomer contains a part of NH, it can be selected to use EJOR from C83218C83326EJOR; - C (O) - C83318326; - aspha - C (O) - O - C8321838383226; - aspha - Y-S (O) 695 - C832183318332626Equi (W is 0, 1, 2 or 0);E. In C832183318326, asphalt, alcoxyl and cyclopentadiene, alternatives of one, two or three alternatives selected in R7501 and 7501 can be selected.Between R7510A, one or more substitutes can be used to replace phenyl.R2 can be replaced by one or more substitutes from hydrogen, halogen, cyanide, C83218331836263, tar, C832183313183266, Alcoxico and C832331836263; cyclopentadiene; among them, C83218331836262, C8321833283226, Alcoxilo and C83838383833183326263; 1. Swimming independently between groups consisting of halogen, hydroxyl and phenyl, where one or more substitutes can be selected between R7510 to replace phenyl.R3 unites from hydrogen, halogen, hydroxyl, C83218383263; tar, C83218383838383838326; - Acoxyl, - S (O) 695 - C83318326; - tar (W is 0, 1, or 2),- No. 749191-C83218331832626; asphalt, C8323833183263; cyclohexane, S(O) 695-C83833183266; cyclohexane (W 0, 1, or 2),- NR 74919-C83323-833183226; -cycloquilo, -o-phenyl, -S(O) 695e-phenyl (W 0, 1, or 2),- Nr.74919-Fenilo, C.83288331; 8322; - Benzocyclohexyl-NR7491; R7495;- OC (O) NR74919 - phenyl - NR7491A - C (O) - O - phenyl - NR7491A - C (O) - C (O) - C8321A - C (O) - C83318326; - alkyl - phenyl - C8321833126; - alkyl - NR7491A - phenyl - NR7491A - C833183226; - alkyl - phenyl, as well as a part of single, bicyclic, cyclic, cyclic, cyclic, cyclohexane - 914 - cyclohexane;A. O straight ring - S (O) 695 - (W is 0, 1, or 2), in which one or two heteroatoms are selected from each group consisting of O, N and S; in this group, if the heterocyclic ring - S, the straight ring - NR74919;O Heterosexual - S (o) 695 - Contains part - NH, optionally from C8321838326; - asphalt, - C (o) - C832138326; - C83318326; - asphalt, - C (o) - O - C832183318326; - asphalt, Y - S (o) 695C832183318326; - asphalt, including 2;There, isopropylene, isopropylene-NR749191,E. Isopropylene-S(o) 695 can be replaced by 1, 2, 3 or 4 alternatives selected between R758484 and R758484 respectively.Among them, this ratio of phenyl-O-phenyl-S(O) 695NR 7491; two or three substitutes Independent selection between R75100A;And C832183318326; - S (o) 695C832183326; (W is 0, 1, or 2),- No. 749191-C83218331832626; asphalt, C8323833183263; cyclohexane, S(O) 695-C83833183266; cyclohexane (W 0, 1, or 2),E.Y-NR74919-C8323183268 cyclo can be selected in R7501 and 7501;R8308 should be from hydrogen group and C8321838326; tar group, of which C83217C8331836262; one, two or three alternatives can be selected to replace each alternative, and the alternatives are from halogen group, hydroxyl group and C832183316326; alcoxyl; or R1; R830808,They combine with sulfur and nitrogen to form a selective one-cycle heteromorphic ring, which is replaced by 5-8 members who can choose an additional heteromorphic atom between O, N and S groups; R7497; 7497Se; A is conducted independently in each case between R7510A groups;Hydrogen, C832183318326; asphalt, C832383318326; cyclopentadiene, C832283318326; asphalt, C832283318326; asphalt, C832253318326; asphalt, C832183318326; Acoxyl, C83218326832683; - asphalt, S(o) 695-;(W is 0, 1 or 2)E.C8321C83318326; - N (R74919) - and C8321833126; - Alcoxiccarbonil-N (R7491) -;C.C832183318326; aspha C832383318326; cyclo; C832283318326; Alquenilo; C8322283318326; aspha Acoxyl; C8321838326838326; asphalt-S (O) 695-;C8321C8331836283; - N bitumen (R749191) -,E.C8321C83318326; - n (R749191) - Alternatives selected from R7510 may be substituted by one or more alternatives;R75484, 758484 were independently selected from halogen, hydroxyl, - NR7491, - R74955 groups in each case.Oxo, C832183318326, alkyl group and C832183318326; alcoxyl; R7501 and 7501 were separately selected from halogen, hydroxyl-NR7491; - R749595;C.C832183318326; asphalt, C8321833183326; Acoxyl, C832383318326; cyclo (optional by independent from halogen, hydroxyl, C832183318C83323; asphalt and C832183331) alcoxicol (alternative by one, two or three atoms); (S) FluorinePhenyl is a single-ring heteromorphic, consisting of 5-6 members, or 8-10 members, each with one, two or three heteromorphic atoms, which are independently selected in a group consisting of O, N and S, and have a single-ring, double-ring bridge and 4-10 member helical rings. S chooses one or two heteroatoms in O, N and S groups, and if the heterocyclic ring contains a part of NH, a substitute can be selected in C8321A group to replace this nitrogen. - 1-1-0-0-0-0-0-0-0-0-0-0-0-0-0-0-0-0-0E.Y-S(o) 695-C83218331-832626 asphalt (W 0, 1, or 2);And where can we choose to replace phenyl with one, two or three alternatives selected between R688A and R688A respectively?At this point, one, two, three or four independently selected substitutes can be chosen to replace the single-ring, double-ring bridge and spiral rings of 4-10 members.R688, 6888 independently from halogen, cyanide, C8321833183326283; tar, C832183836263; - alcoxyl, S (o) 695 - C8321833183323; - tar, - S (o) 695 - NR7491; - R74955;- No. 74919-S (O) 695-C832183318333; Asphalt (W 0, 1, or 2),Each member has one, two or three different atoms, which are independently selected from the group composed of O, N and S, and a single ring composed of 4-7 members. Each member has one or two different atoms, and each member chooses independently. Siste en O, N, y S; C832183318326; - alcoxyl and S (o) 695e - C832183318383838323; - alternative tar with one, two or three halogens; R8305; - 8305 is selected independently from halogens, hydroxyl - NR7491; - R74955;OXO, C832121838331 degree-8326, tar and C8321838331 degree-8326, tar and C8321838383838383838326;alcoxicol; Ra1, independently selected from hydrogen, halogen, C83212183838383838383832326 tar, C8322838383838383832326, Alquenilo, C838383838383838383838383838326 asphalt, C832183838383838383838383833226; Alcoxiclo, Alcoxiclo, C832183838383838383838383838383838383838383838383832326;;;;;;;;;;;;;;;;;;;;;; CCCCCCCCCCCCCCCCCC8322222222222222222222222222222222222222222222222222222222222222222222222222222222222222228326;;; "R74955,- O-C(O) -NR7491-phenyl-phenyl-phenyl-phenyl-NR7491-phphphenyl-NR7491-C(O) -phenyl-phenyl, Y-NR7491-C83832183838383838331, S 8324 ribo-phenyl; CC8383832331-8326 tar, CC838383838383838331832326, AlQuenilo, C838383838331833183lalalalalalalalalo, C8383838383318326, Ginilo, C838383838383838391-phphphphphphphphphenyl, Y-NR7491-phenyl, Y-NR7491-C8383838383Replacement of members 4. Halogen, hydroxyl, phenyl and Y-NR7491; R74955;RX1 from hydrogen, halogen, cyanide, C832121; by one, or S or three substitutes selected from hydroxyl and halogen groups; among these substitutes, one or more substitutes selected from R7510 can be used to replace phenyl.Rx2 can replace phenyl with hydrogen, halogen, C83218331836263; tar, C83217C833183263; - alcoxyl, Y-C83216C83318326; - alcox-fenilo; among them, one or more substitutes selected from R7510 can be used.RX3 3 is from hydrogen, halogen, cyanide, C8321; by one, or S or three substitutes selected from hydroxyl and halogen groups; among these substitutes, one or more substitutes selected from R7510 can be used to replace phenyl.R7510 in each case from halogen, hydroxyl, cyanide, C83218331833262; tar, C832383318326; cyclic chlorine, C832183316326; oxygen, phenyl, C8321833183226; cyclic methoxy group, S (o) 695C8321833183838383830; tar, including 230;- S (O) 695-7491; R74955;Y-NR 7491; R74955;E.R749191 and R747595 are independently selected from the hydrogen group, C832183836263; - tar, phenyl, - C(O) - phenyl, Y-C(O) - C832183318326; - tar; C8321838383226; - tar, phenyl, - C(O) - phenyl, Y-C(O) - C83218331832683; - one or more alternatives can be selected; 1. Titles selected from halogen, cyanide, Oxo and hydroxyl groups, or R7491 and R74955, form a heterocycle with the attached nitrogen.
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