nucleic acid construct, transfer vector plasmid, vector, cells, virus particle, composition and active ingredient set

摘要

nucleic acid construct, transfer vector plasmid, vector, cell, virus particle and composition or set of active ingredients The invention relates to recombinant measles viruses expressing chikungunya virus polypeptides and particularly relates to virus-like particles (vlp) containing envelope and capsid proteins of a chikungunya virus on their surfaces. These particles are recombinant infectious particles capable of replicating in a host following administration. The invention provides means, particularly nucleic acids, vectors, cells and rescue systems for producing such recombinant infectious particles. The invention also relates to the use of such recombinant infectious particles, particularly in the form of a composition, more particularly in a vaccine formulation, for the treatment or prevention of a chikungunya virus infection.