CONSTRUCTION OF NUCLEIC ACID, PLASMIDIAL TRANSFER VECTOR, TRANSFORMED CELLS, SPAM-VIRUS ZIKA VIRUSES (MV-ZIKV), COMPOSITION OR SET OF ACTIVE INGREDIENTS, AND PROCESS FOR RECOVERING VIRUS-VIRUSES

摘要

the present invention relates to recombinant measles viruses that express Zika virus proteins and their applications, particularly in inducing preventive protection against the Zika virus. the present invention is directed to the recombinant measles virus (mv) which expresses at least (i) the precursor of the membrane protein (prm) of a zika virus (zikv) and the envelope protein (e) of a zikv or a version truncated, or (ii) the protein and a zikv or a truncated version of the same, and concerns the recombinant infectious particles of said mv-zikv capable of replicating in a host after administration, and also concerns the particles similar to viruses (vlps) that contain these zikv proteins on their surfaces. the present invention provides means, particularly nucleic acids, vectors, cells and recovery systems for producing such recombinant infectious particles and vlps. the present invention also relates to the use of these recombinant infectious particles and / or vlps, in particular in the form of a composition, more particularly in a vaccine formulation, for the prevention of a zikv infection or for the preventive protection against outcomes clinical signs of zikv infection.