zic1 and ghsr molecular diagnostic markers for hpv-induced invasive cancers, non-hpv-induced gynecological and anogenital cancers, and their high-grade precursor lesions

摘要

The invention relates to the method for detecting hpv-induced high-grade precancerous lesions, hpv-induced invasive cancers and hpv-induced gynecological and anogenital cancers, said method comprising detecting hypermethylation in the zic1 and / or ghsr gene in a cell. Therefore, such hypermethylation indicates the presence of hpv-induced precursor lesions with invasive potential, hpv-induced invasive cancer, and non-hpv-induced gynecological and anogenital cancers. The invention further comprises the use of the zic1 and / or ghsr gene in such a method and a test kit for detecting zic1 and / or ghsr methylation.