The molecular diagnostic markers ZIC1 and GHSR for HPV-induced invasive cancer, non-HPV-induced gynecological and anal genital cancer and their high-grade precursor lesions

摘要

The present invention relates to a method for detecting HPV-induced high-grade pre-cancerous lesions, HPV-induced invasive cancer and non-HPV-induced gynecologic and anal genital cancers, And methylation, which indicate the presence of HPV-induced precursor lesions with invasive potential, HPV-induced invasive cancer and non-HPV-induced gynecological and anal genital cancer. The invention also relates to a test kit for the detection of ZIC1 and / or GHSR methylation and the use of ZIC1 and / or GHSR genes in such a method.