method of producing a coating solution, coating solution, substrate coating method, medical device, and sealed packaging

摘要

method of producing a coating solution, coating solution, substrate coating method, medical device, and sealed package, comprises method of producing a coating solution, including the polymerization steps of an initial monomer feed comprising an n-vinylpyrrolidone monomer and an acrylate salt, preferably methacrylate, in water to synthesize a respective copolymer, acidifying the resulting copolymer-water mixture to provide carboxylic acid free groups throughout the copolymer structure, diluting the aqueous solution with alcohol and adding a crosslinking agent that is capable of reacting with the carboxylic acid groups and curing the copolymer at a later stage after the coating solution has been applied to a substrate and the coated copolymer therein; Also disclosed is a storage coating solution, a method for coating a substrate that is on or is part of a medical device or other article, a substrate, article or medical device having such a coating applied and a medical device coated on a hydration solution; The aqueous alcoholic coating solution may be stored for a prolonged period, suitably for at least one month and desirably for substantially longer without deterioration.