t-cell receptor, t-cell receptor anti-cd3 fusion molecule, nucleic acid, expression vector, cell, non-naturally occurring or isolated cell and pharmaceutical composition

摘要

t cell receptor, t cell receptor anti-cd3 fusion molecule, nucleic acid, expression vector, cell, isolated or non-naturally occurring cell and pharmaceutical composition The present invention relates to t cell receptors (tcrs) which bind to the slyntvatl restricted hla-a * 02 peptide (sequence id: 1) derived from the hiv gag gene product, p17. said tcrs comprise unnatural mutations within the alpha and / or beta variable domains relative to a natural hiv tcr. The TRIs of the invention have unexpectedly high affinity, specificity and sensitivity to a complex of sequence id: 1 and hla-a * 02, and trigger a particularly potent t cell response. These compounds are particularly useful in the development of soluble immunotherapeutic reagents for the treatment of HIV-infected individuals.