novel forms in 3- (1,2,4-triazol 4,3-a pyridin-3-ylethynyl) -4-methyl-n- (4 - ((4-methylpiperazin-1-yl) methyl) crystalline salt ) -3-trifluoromethylphenyl) benzamide for medical application

摘要

The invention relates to organic chemistry, pharmacology and medicine and is concerned with the prevention and treatment of human and animal diseases associated with disruption in the activity of various kinases, in particular abl kinase, for example diseases such as leukemia, acute myeloid leukemia, leukemia. chronic myeloid, acute lymphocytic leukemia, breast cancer, non-small cell lung cancer, gastrointestinal stromal tumors, ovarian cancer, lymphoma, using a new salt form of 3- (1,2,4-triazole [4,3 -a] pyridin-3-ylethynyl) -4-methyl-n- (4 - ((4-methylpiperazin-1-yl) methyl) -3-trifluoromethylphenyl) benzamide. The salt of this compound with methanesulfonic acid, formula (I), or its hydrate, solvate, as well as polymorphic modifications, has the ability to inhibit the activity of kinases, in particular of ab1 kinases. The present invention also relates to pharmaceutical compositions comprising a therapeutically effective amount of a salt of the invention, a method for preparing a crystalline salt of the invention, as well as a method for treating oncological diseases in a patient.