RECOMBINANT MUTANT OF ASFV-G (AFRICAN SWINE FEVER VIRUS ISOLATED GEORGIA 2007), CDNA MUTANTE, VACCINE COMPOSITION, PROCEDURE FOR SWINE PROTECTION AGAINST SWINE Fever Virus ISOLATED GEORGIA 2007, (ASFV-M) DIFFERENTIATING A VACCINATED MAMMALIAN WITH AN ASFV-G LIVE ATTITUTED VACCINE - 9GL / UK

摘要

African swine fever virus (ASFV) is the etiological agent of an often lethal contagious viral disease of domestic pigs. Control of African swine fever is hampered by lack of vaccine availability. experimental vaccines have been derived from naturally occurring attenuated live asfvs, adapted to cell culture or genetically modified; however, these vaccines are only successful in protecting against homologous viruses.we constructed a recombinant 9gl / uk virus derived from the highly virulent asfv isolate georgia 2007 (asfv-g) by deletion of the specific 9gl (b119l) and uk (dp96r) genes associated with virulence. in vivo, asfv-g - 9gl / - uk, administered intramuscularly to pigs, even at relatively high doses (106 had50) does not induce disease. substantially, animals infected with 104 or 106 had50 are strongly protected against exposure to clinical disease when challenged 28 days after infection with the virulent parental germ strain 2007.