A Strain of attenuated virus of African Swine Fever developed rationally, protects against infection by the 2007 Georgia parental virus isolated.

摘要

African swine fever virus (asfv, for its acronym in English) is the agent of a etiolÓgico, Contagious viral disease, often Lethal, of domestic Pigs.The Control of African Swine Fever (ASF) has been hindered by the lack of availability of Vaccines.Experimental Vaccines have been derived Live Attenuated asfv, adapted to cells or genetically modified crops; however,These Vaccines are successful only when protection against homologous virus.We constructed a recombinant virus d9gl / Duk Derivative of asfv virus (asfv - 2007 Georgia (g) highly virulent to eliminate specific genes associated with virulence 9GL (b119l) and the UK (dp96r). In vivo, VPPA - G / d9gl Duk administered by intramuscular route to Pigs, even at relatively high doses (106had50) does not induce disease.It is important to note that animals infected with 104 or 106 had50 sÓlidamente are protected against Clinical presentation of the disease when the race at 28 days after LInfection with the virulent Parent Strain to Georgia in 2007.