METHODS FOR DETECTION OF PRECISION FOR OR STAGE OF A CANCER IN A MAMMALIAN, FOR SCREENING, IDENTIFICATION OR OPTIMIZATION OF AN ANTI-CANCER MEDICINE, FOR MODIFICATION OF AN IN VITRO EVALUATION EVALUATION EVALUATION EVALUATION CANDIDATE CANCER OR MEDICINAL PRODUCT

摘要

methods for detecting cancer pre-disposition or stage in a mammalian subject, for screening, identifying or optimizing an anti-cancer drug, for modifying a mammalian gene in vitro and for evaluating the efficacy of an anti-cancer drug Cancer or a candidate drug of the present invention relates to the identification of a novel mechanism of cell transcription infidelity. The invention provides compositions and methods for detecting the level of ion transcription infidelity in a sample, as well as the use thereof, for example for therapeutic, diagnostic, pharmacogenomic or drug projects. As will be disclosed, the invention is particularly suited for detecting, monitoring or treating cell proliferative disorders, for the design and / or screening of drugs, for profiling the individual or disease, predicting the severity of the disease and evaluating the disease. efficacy of the drug.