The present disclosure relates generally to compositions and methods for treating cancer and neoplastic diseases. Provided herein are substituted pyridine derivative compounds and pharmaceutical compositions comprising said compounds of the general formula; ;The subject compounds and compositions are useful for inhibition of histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.
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机译:本公开总体上涉及用于治疗癌症和赘生性疾病的组合物和方法。本文提供了取代的吡啶衍生物化合物和包含所述通式化合物的药物组合物; <图像文件=“ IMGA0002.GIF” he =“ 19” imgContent =“绘图” imgFormat =“ GIF” wi =“ 33” /> ;本发明的化合物和组合物可用于抑制组蛋白脱甲基酶。此外,本发明的化合物和组合物可用于治疗癌症,例如前列腺癌,乳腺癌,膀胱癌,肺癌和/或黑素瘤等。
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