Blood circulation diagnosis medication o-sulfonamide benzoic acid synthesis method, comprises thefollowing steps:3 mol 2-benzene sulfonamide-6-bromo-isophenone and 4-5 mol ethylene glycol monoisopropyl ether were added to the reaction vessel, controlled the stirring speed of 130-160 rpm for 30-40 min, and then raise the temperature of the solution to 40-50 °C, 5-6 mol tetrabutyl titanate was added to the reaction vessel by 5-8 times, which was added every 20-30 min, the temperature was controlled at the 55-60 °C, itwas maintained for 130-150 min, then the temperature is reduced to 10-13 °C, the solid is precipitated, filtered and washed with the potassium bromide solution, the pH of the solution is adjusted to 4-5, then the solid is precipitated again, filtered, and washed with the dipropylamine solution, and washed with the dichlorobenzene solution, recrystallizated in ether solution, got the finished o-sulfonamide benzoic acid.
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