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Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof
Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof
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机译:Prins反应和中间体可用于合成蛇绿素大环内酯及其类似物
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摘要
The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditions to afford a macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides or analogs thereof and methods for preparing the same.
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