Method for determination of tissue sensitivity to insulin, method for identification of insulin resistance and/or determination of predisposition to a disorder related to it, application of the insulin sensitivity index and the diagnostic kits, and their application

摘要

the subject of this application is a method of marking the sensitivity of tissues to insulin in person, namely thatthe blood samples taken from individuals with full isolated rna and measured expression following gene: klf9,pemt and egr1; and on the basis of the results obtained is insulinowrażliwości ratio measurements.the subject of this application is also way identification of insulin resistance and / or determining the predisposition to the disorder associated with insulinoopornością in person, namely thatthe blood samples taken from individuals with full isolated rna and measured expression following gene: klf9,pemt and egr1; on the basis of performance measurements means the ratio insulinowrażliwości,and on the basis of the result of the insulinowrażliwości identifies and determines predisposition to insulin resistance disorders associated with insulinoopornością.the subject of this application is also the insulinowrażliwości for use as a diagnostic biomarker, to use as a biomarker insulin resistanceto use as a biomarker associated with insulinoopornością outlook disorders and to apply to the determination of the predisposition to the disorder associated with insulinoopornością.the object of the application is also applicable to the insulinowrażliwości monitoring tissue sensitivity to insulin.especially in the course of disorder and / or disease associated with insulinoopornością, particularly type 2 diabetes.in addition, the subject of this invention are diagnostic kits for implementing such methods and their application to forecasting, diagnosis, including early diagnosis,and / or monitoring therapy of disorders associated with insulinoopornością.