首页> 外国专利> Method for obtaining extract from Cochlospermum angolense with anti-tumor activity and application of the extract from Cochlospermum angolense in treatment of myeloma

Method for obtaining extract from Cochlospermum angolense with anti-tumor activity and application of the extract from Cochlospermum angolense in treatment of myeloma

机译:一种具有抗肿瘤活性的香叶提取物的制备方法及在骨髓瘤治疗中的应用

摘要

The purpose of the notification is to obtain an extract from Cochlospermum angolensis (Borututu) by treating the contaminated plant substance Borututu with chloroform, preferably twice, each time for 12 -72 hours preferably 48 hours, using favourable quantities first 1:20, then 1:10,after which the chloroform macerat e or the combined macerates evaporate at a temperature not exceeding 40oC and the dry residue (SP) is mixed with silicon gel in a weight ratio of 1:1 to 1:100 favourable 1:10 and further extracted in the liquid /solid system p ris the use of hexane or ethyl acetate and /or a mixture of them favourably in proportion 1:1, after eluent evaporation, a fraction with a high anti -cancer activity is obtained. An extract of Cochlospermum angolense Welw is also included. ex Olive. Son. Maximilianea angolensis (Welw). ex Oliv.),obtained by two -stage extraction: maceration with chloroform and extraction with hexane or ethyl acetate and /or a mixture thereof (Ex2) and use of the extract in the treatment of marrow.
机译:通报的目的是通过用氯仿处理受污染植物物质Borututu(优选两次),每次12 -72小时,优选48小时,以有利的比例首先以1:20,然后是1的比例从安氏香菇(Cochlospermum angolensis)中提取提取物。 1:10,然后在不超过40oC的温度下蒸发氯仿浸出物或合并的浸出物,然后将干燥残留物(SP)与硅胶按1:1至1:100的重量比混合,以有利的1:10比例混合,再进一步在液体/固体系统中萃取的溶液中,使用己烷或乙酸乙酯和/或它们的混合物以1:1的比例有利,洗脱液蒸发后,获得具有高抗癌活性的馏分。还包括安哥拉天竺葵的提取物。前橄榄。儿子。 Maximilianea angolensis(Welw)。通过两步萃取获得:用氯仿浸渍并用己烷或乙酸乙酯和/或其混合物(Ex2)萃取,并将该萃取物用于骨髓治疗。

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