Procedure for the preparation of dipeptide derivatives of lysine-glutamic acid

摘要

Process for the preparation of compounds of formula I ** Formula ** in which R2 is hydrogen, comprising a) coupling the glutamic acid derivative of formula ** Formula ** in which R1 is hydrogen or an ester protecting group and R4 is C12-20 alkyl, or a salt thereof with a lysine derivative of formula ** Formula ** in which R2 'is an ester protecting group and R3 is hydrogen or an amino protecting group, or a salt thereof to form a compound of formula ** Formula ** in which R1, R2 ', R3 and R4 are as above and b) remove the ester protecting group R2'.