A process catalyzed by lipase to provide concentrates high in docosahexaenoic acid (DHA), comprising the steps: i) direct esterification of free fatty acids from fish oil with ethanol at 20-40 ° C in the presence of Rhizomucor miehei lipase (MML) ) immobilized on a vehicle; ii) separation of the ethyl esters enriched in eicosapentaenoic acid (EPA) from the free fatty acids rich in DHA by short-path distillation.
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