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EXPRESSION OF METABOLIC MODULATORS IN TUMOR MICROENVIRONMENT TO IMPROVE TUMOR THERAPY
EXPRESSION OF METABOLIC MODULATORS IN TUMOR MICROENVIRONMENT TO IMPROVE TUMOR THERAPY
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机译:代谢调节剂在肿瘤微环境中的表达改善肿瘤的治疗
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摘要
Recombinant oncolytic viruses (OVs) that express one or more metabolic modulator proteins, such as an adipokine (e.g., leptin or chemerin), insulin, and/or IGF- 1, and methods of their use to treat cancer, for example in immunotherapy anti-cancer treatments. In some examples, such recombinant OVs and methods increase T cell infiltration into the tumor or tumor microenvironment.
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